(+)-2,2'-Methylenebis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazole]

Structure

(+)-2,2'-Methylenebis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazole]
General Information
TCI Product No. : M1401
Stock Status :
Unit Sizes Price Available stock
Belgium Tokyo *
500MG 75.00 EUR Please contact us. Please contact us.
1G 121.45 EUR 3 10

Status at 03:00 a.m. on 08 Feb 2012

* Items available from stock in Japan will be delivered in 10 business days
Purity / Analysis Method : >98.0%(LC)(N)
Storage :
M.F. / M.W. : C21H18N2O2=330.39
CAS Number : 180186-94-1
Related CAS Number :
MDL Number : MFCD06797115
Data of Reference
mp : 225 °C
[α]20D : 360 ° (C=1, CH2Cl2)
Application

Oxidative Trifluoromethylation of Indoles

Oxidative Trifluoromethylation of Indoles

Typical Procedure: In a 4 mL TFE sealed glass vial, Pd(OAc)2 (4.4 mg, 0.02 mmol), PhI(OAc)2 (129 mg, 0.4 mmol), (+)-2,2'-methylenebis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazole] (9.8 mg, 0.03 mmol), and TEMPO (15 mg, 0.1 mmol) are added. The glass vial is transferred to a glove box to add CsF (122 mg, 0.8 mmol), and the solution of the indole (0.2 mmol) in anhydrous CH3CN (2 mL) is added. Sequentially, TMSCF3 (0.8 mmol, 120 μL) is immediately added and the mixture is stirred for 6 hours at room temperature. After the reaction is completed, the solvent is removed under reduced pressure, and the residue is purified by fast chromatography in silica gel to give the desired compound.
Safety
Signal Word : Warning
GHS H Statement : Causes mild skin irritation. Causes eye irritation.
GHS P Statement : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation occurs: Get medical advice/attention. Wash hands thoroughly after handling. If eye irritation persists: Get medical advice/attention.
Informative Links
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Related Categories :
Synthetic Organic Chemistry Asymmetric Synthesis

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