2,4,6-Triisopropylbenzenesulfonyl Chloride

General Information
TCI Product No. : T0459
Stock Status :
Unit Sizes Price Available stock
Belgium Tokyo *
25G 60.00 EUR 2 9
500G 591.45 EUR 1 3

Status at 03:00 a.m. on 08 Feb 2012

* Items available from stock in Japan will be delivered in 10 business days
Purity / Analysis Method : >95.0%(T)
Storage : Refrigerator
M.F. / M.W. : C15H23ClO2S=302.86
CAS Number : 6553-96-4
Related CAS Number :
MDL Number : MFCD00007433
Data of Reference
mp : 96 °C
Application

Efficient synthesis of N2-dimethylaminomethylene-2’-O-methylguanosine

Efficient synthesis of N2-dimethylaminomethylene-2’-O-methylguanosine

Typical procedure (protection of the O6-position of guanosine): To a suspension of 3’,5’-O-di-tert-butylsilanediylguanosine (2.12 g) in dry CH2Cl2 are added DMAP (0.122 g), Et3N (4.18 mL), and 2,4,6-triisopropylbenzenesulfonyl chloride (4.68 g) under argon. The reaction mixture is stirred at room temperature for 3 h and then the solvent is removed under reduced pressure. The residue is dissolved in ethyl acetate and the solution is washed with saturated NaHCO3 solution and brine, and dried over Na2SO4. After filtration, the solvent is evaporated in vacuo. The residue is purified by column chromatography (eluent: 50-60 % CHCl3 in hexane) to give the O6-protected guanosine as a colorless foam (3.34 g, 97%).
References
F & F : 6, 622
EC Number : 229-479-6
Transport Information
UNNo. : 3261
Class : 8
PG : III
Safety
Signal Word : Danger
Pictogram : Corrosion
GHS H Statement : May be corrosive to metals. Causes severe skin burns and eye damage.
GHS P Statement : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Do not breathe. Wear protective gloves/eye protection/face protection. IF SWALLOWED: rinse mouth. Do NOT induce vomiting. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Risk Phrases
R34 : Etsende.
Safety Phrases
S26 : Får man stoffet i øynene, skyll straks grundig med store mengder vann og kontakt lege.
S36/37/39 : Bruk egnede verneklær, -hansker og -briller/ansikts- sjerm.
S45 : Ved uhell eller illebefinnende er omgående legebehandling nødvendig, vis etiketten hvis mulig.
Informative Links
TCI Product Literature :
Related Categories :
Synthetic Organic Chemistry Condensation & Active Esterification
Biochemistry Nucleosides, Nucleotides & Related Reagents Protecting Agents, Phosphorylating Agents & Condensing Agents Protecting Agents for Hydroxyl and Amino Groups
Biochemistry Nucleosides, Nucleotides & Related Reagents Protecting Agents, Phosphorylating Agents & Condensing Agents Condensing Agents (DNA / RNA Synthesis)
Synthetic Organic Chemistry Sulfur Compounds (for Synthesis) Sulfonic Acid Derivatives Sulfonic Acid Derivatives (Others)

Page Top